@prefix dcterms: . @prefix this: . @prefix sub: . @prefix beldoc: . @prefix rdfs: . @prefix rdf: . @prefix xsd: . @prefix dce: . @prefix pav: . @prefix np: . @prefix belv: . @prefix prov: . @prefix schem: . @prefix go: . @prefix scomp: . @prefix ProteinComplex: . @prefix hasAgent: . @prefix obo: . @prefix occursIn: . @prefix species: . @prefix orcid: . sub:Head { this: np:hasAssertion sub:assertion; np:hasProvenance sub:provenance; np:hasPublicationInfo sub:pubinfo; a np:Nanopublication . } sub:assertion { scomp:Na%2FK%20Exchanging%20ATPase%20Complex a ProteinComplex: . sub:_1 hasAgent: scomp:Na%2FK%20Exchanging%20ATPase%20Complex; a go:0005215 . sub:_2 occursIn: obo:CL_0000746, obo:UBERON_0000948, species:9606; rdf:object sub:_1; rdf:predicate belv:increases; rdf:subject schem:Adenosine%20triphosphate; a rdf:Statement . sub:assertion rdfs:label "a(SCHEM:\"Adenosine triphosphate\") -> tport(complex(SCOMP:\"Na/K Exchanging ATPase Complex\"))" . } sub:provenance { beldoc: dce:description "Approximately 61,000 statements."; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved."; dce:title "BEL Framework Large Corpus Document"; pav:authoredBy sub:_5; pav:version "20131211" . sub:_3 dce:identifier "Golan Document"; dce:title "Golan Document"; dce:type "Other" . sub:_4 prov:value "Sodium-pump activity is closely linked to the intracellular calcium concentration via the sodium-calcium exchanger; this antiporter exchanges sodium and calcium in both directions across the sarcolemma. Changes in the concentration of either sodium or calcium ions inside or outside the cell affect the direction and magnitude of sodium-calcium exchange. Under normal conditions, the low intracellular sodium concentration favors sodium influx and clacium efflux. Some drugs take advantage of the functional coupling etween the sodium pump and the sodium-calcium exchanger to exert their effect as positive inotropes. Digoxin is the prototype of an inotropic agent that acts by inhibiting the sodium pump. A sarcolemmal calcium pump also helps to maintain calcium homeostasis by actively extruding calcium from the cytoplasm after cardiac contraction. A high concentration of ATP favors calcium removal (relaxation), both directly via the calcium pump and indirectly via the sodium pump."; prov:wasQuotedFrom sub:_3 . sub:_5 rdfs:label "Selventa" . sub:assertion prov:hadPrimarySource sub:_3; prov:wasDerivedFrom beldoc:, sub:_4 . } sub:pubinfo { this: dcterms:created "2014-07-03T14:31:29.119+02:00"^^xsd:dateTime; pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 . }