@prefix this: . @prefix rdfs: . @prefix xsd: . @prefix sio: . @prefix ncit: . @prefix lld: . @prefix miriam-gene: . @prefix miriam-pubmed: . @prefix eco: . @prefix wi: . @prefix prov: . @prefix pav: . @prefix prv: . @prefix dcterms: . @prefix np: . @prefix dgn-np: . @prefix dgn-gda: . @prefix dgn-void: . dgn-np:NP651940.RAqHfH-9kZAmQKkCC1Qtu-2LiWyKXeoap1gCEok4mPMXo130_head { this: np:hasAssertion dgn-np:NP651940.RAqHfH-9kZAmQKkCC1Qtu-2LiWyKXeoap1gCEok4mPMXo130_assertion; np:hasProvenance dgn-np:NP651940.RAqHfH-9kZAmQKkCC1Qtu-2LiWyKXeoap1gCEok4mPMXo130_provenance; np:hasPublicationInfo dgn-np:NP651940.RAqHfH-9kZAmQKkCC1Qtu-2LiWyKXeoap1gCEok4mPMXo130_publicationInfo; a np:Nanopublication . dgn-np:NP651940.RAqHfH-9kZAmQKkCC1Qtu-2LiWyKXeoap1gCEok4mPMXo130_assertion a np:Assertion . dgn-np:NP651940.RAqHfH-9kZAmQKkCC1Qtu-2LiWyKXeoap1gCEok4mPMXo130_provenance a np:Provenance . dgn-np:NP651940.RAqHfH-9kZAmQKkCC1Qtu-2LiWyKXeoap1gCEok4mPMXo130_publicationInfo a np:PublicationInfo . } dgn-np:NP651940.RAqHfH-9kZAmQKkCC1Qtu-2LiWyKXeoap1gCEok4mPMXo130_assertion { miriam-gene:5704 a ncit:C16612 . lld:C3825627 a ncit:C7057 . dgn-gda:DGNfd019eac7d4c1535ef6a82bff893de2e sio:SIO_000628 miriam-gene:5704, lld:C3825627; a sio:SIO_001122 . } dgn-np:NP651940.RAqHfH-9kZAmQKkCC1Qtu-2LiWyKXeoap1gCEok4mPMXo130_provenance { dgn-np:NP651940.RAqHfH-9kZAmQKkCC1Qtu-2LiWyKXeoap1gCEok4mPMXo130_assertion dcterms:description "[Several lines of evidence suggest a mechanistic link between the ER-stress protecting function of TRAP1 and resistance to anthracyclins: i) ER stress- and anthracyclin-resistant cell lines are characterized by the upregulation of TRAP1; ii) TRAP1 silencing in both drug-resistant cell models restored the sensitivity to bortezomib and anthracyclins; iii) the transfection of a TRAP1 deletion mutant, whose localization is restricted to the ER, in TRAP1 KD cells protected from apoptosis induced by anthracyclins; iv) the disruption of the ER-associated TRAP1/TBP7 pathway by a TBP7 dominant negative deletion mutant re-established drug sensitivity in drug-resistant cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en; wi:evidence dgn-void:source_evidence_literature; sio:SIO_000772 miriam-pubmed:24297638; prov:wasDerivedFrom dgn-void:befree-20150227; prov:wasGeneratedBy eco:ECO_0000203 . dgn-void:befree-20150227 pav:importedOn "2015-02-27"^^xsd:date . dgn-void:source_evidence_literature a eco:ECO_0000212; rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en; rdfs:label "DisGeNET evidence - LITERATURE"@en . } dgn-np:NP651940.RAqHfH-9kZAmQKkCC1Qtu-2LiWyKXeoap1gCEok4mPMXo130_publicationInfo { this: dcterms:created "2015-08-25T14:44:11+02:00"^^xsd:dateTime; dcterms:rights ; dcterms:rightsHolder dgn-void:IBIGroup; dcterms:subject sio:SIO_000983; prv:usedData dgn-void:disgenetv3.0rdf; pav:authoredBy , , , , ; pav:createdBy ; pav:version "v3.0.0.0" . dgn-void:disgenetv3.0rdf pav:version "v3.0.0" . }