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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAqDSCEqVw6bfWUaNYMHPXrdnakldGgfDmDP4CEfDWtXE#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAqDSCEqVw6bfWUaNYMHPXrdnakldGgfDmDP4CEfDWtXE#_5 http://www.w3.org/ns/prov#value The PI3K pathway is negatively regulated by PTEN (phosphatase and TENsin homolog), which converts PIP3 in PIP2, preventing PKB activation and Bad phosphorylation/sequestration. Thus PTEN is considered as a tumor suppressor gene. 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