http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#Head http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#assertion http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#provenance http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#pubinfo http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#assertion http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/UBERON_0000160 http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116 http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-diseases/tissue%20damage http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://purl.bioontology.org/ontology/MSH/D007511 http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#assertion http://www.w3.org/2000/01/rdf-schema#label path(MESHD:Ischemia) -> path(SDIS:"tissue damage") http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#_3 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#_2 http://www.w3.org/ns/prov#value BACKGROUND: We have shown that both intraischemic hypothermia and hypertonic saline resuscitation provide dramatic protection against gut ischemia/reperfusion (I/R) injury that is in part mediated by heme oxygenase-1 (HO-1). We therefore hypothesized that induction of HO-1 by hemin would lessen damage and improve function after gut I/R. MATERIALS AND METHODS: Male Sprague-Dawley rats were treated with 50 micromol/kg hemin (HO-1 inducer ferric protoporphyrin IX chloride) sq or vehicle 2 h before superior mesenteric artery occlusion for 60 min or sham laparotomy. After 6 h of reperfusion, transit was determined by quantitation of percentage of tracer in 10 equal segments of small intestine 30 min following injection into the duodenum (expressed as mean geometric center). Ileum was harvested for assessment of mucosal histologic injury (Chiu score 0-5 by blinded observer), myeloperoxidase activity (MPO, index of inflammation), and HO-1 protein expression. RESULTS: Hemin treatment was associated with increased HO-1 protein expression, lessened mucosal injury, decreased MPO activity, and improved intestinal transit following gut I/R. CONCLUSION: These data corroborate that HO-1 plays an important role in protecting the gut against I/R-induced injury. http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15093717 http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15093717 http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#_2 http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k#pubinfo http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k http://purl.org/dc/terms/created 2014-07-03T14:32:20.095+02:00 http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAprX2bXIAEpMF2cuVraHHE5qPN4trOHEEDSOQz60314k http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234