@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAppgcZkfHZrN6J46RQ8E7vH8POe612RCkUE9SfbWW7fA> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAppgcZkfHZrN6J46RQ8E7vH8POe612RCkUE9SfbWW7fA#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix do: <http://disease-ontology.org/term/DOID:> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 occursIn: do:162, obo:CLO_0001230, obo:CL_0000066, obo:UBERON_0000310, species:9606;
    rdf:object go:0008283;
    rdf:predicate belv:decreases;
    rdf:subject chebi:6801;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(CHEBI:metformin) -| bp(GOBP:\"cell proliferation\")" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_3;
    pav:version "20131211" .
  
  sub:_2 prov:value "Recent data suggest that this pharmacological activation of AMPK may also be beneficial for treatment of established tumors with intact Lkb1– AMPK–TSC signaling, as metformin slows proliferation of cancer cell lines (Zakikhani et al., 2006).";
    prov:wasQuotedFrom pubmed:19029933 .
  
  sub:_3 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:19029933;
    prov:wasDerivedFrom beldoc:, sub:_2 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:29.429+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}