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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RApIcwnx7fWPxcV0Bd5oGlGQMLCiq8LxjASpLsZ7qTUOY#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RApIcwnx7fWPxcV0Bd5oGlGQMLCiq8LxjASpLsZ7qTUOY#_5 http://www.w3.org/ns/prov#value To determine the cytotoxic effects and the type of cell death facilitated by TNF in A549 cells, we treated cells with TNF and analyzed cell death based on morphological and biochemical assays. The death rate of A549 cells increased with increasing concentration of TNF (Fig. 1b), and cell death was characterized by cytoplasmic condensation and pyknotic nuclei without apoptotic body formation (Fig. 1c). Dose-dependent release of LDH into the culture medium was also noted (Fig. 1d); this is frequently encountered after necrotic cell death due to rupture of the cell membrane....Thus, TNF triggers necrotic rather than apoptotic cell death in A549 cells. http://www.tkuhn.ch/bel2nanopub/RApIcwnx7fWPxcV0Bd5oGlGQMLCiq8LxjASpLsZ7qTUOY#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/20963496 http://www.tkuhn.ch/bel2nanopub/RApIcwnx7fWPxcV0Bd5oGlGQMLCiq8LxjASpLsZ7qTUOY#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RApIcwnx7fWPxcV0Bd5oGlGQMLCiq8LxjASpLsZ7qTUOY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/20963496 http://www.tkuhn.ch/bel2nanopub/RApIcwnx7fWPxcV0Bd5oGlGQMLCiq8LxjASpLsZ7qTUOY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RApIcwnx7fWPxcV0Bd5oGlGQMLCiq8LxjASpLsZ7qTUOY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RApIcwnx7fWPxcV0Bd5oGlGQMLCiq8LxjASpLsZ7qTUOY#_5 http://www.tkuhn.ch/bel2nanopub/RApIcwnx7fWPxcV0Bd5oGlGQMLCiq8LxjASpLsZ7qTUOY#pubinfo http://www.tkuhn.ch/bel2nanopub/RApIcwnx7fWPxcV0Bd5oGlGQMLCiq8LxjASpLsZ7qTUOY http://purl.org/dc/terms/created 2014-07-03T14:33:40.062+02:00 http://www.tkuhn.ch/bel2nanopub/RApIcwnx7fWPxcV0Bd5oGlGQMLCiq8LxjASpLsZ7qTUOY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RApIcwnx7fWPxcV0Bd5oGlGQMLCiq8LxjASpLsZ7qTUOY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234