@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP466488.RApBCcS-BzE_HBD-gXWl91-x8b_uGYXHVRt5xRivB4QNU> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v4.0.0/void/> .

dgn-np:NP466488.RApBCcS-BzE_HBD-gXWl91-x8b_uGYXHVRt5xRivB4QNU130_head {
  this: np:hasAssertion dgn-np:NP466488.RApBCcS-BzE_HBD-gXWl91-x8b_uGYXHVRt5xRivB4QNU130_assertion;
    np:hasProvenance dgn-np:NP466488.RApBCcS-BzE_HBD-gXWl91-x8b_uGYXHVRt5xRivB4QNU130_provenance;
    np:hasPublicationInfo dgn-np:NP466488.RApBCcS-BzE_HBD-gXWl91-x8b_uGYXHVRt5xRivB4QNU130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP466488.RApBCcS-BzE_HBD-gXWl91-x8b_uGYXHVRt5xRivB4QNU130_assertion a np:Assertion .
  
  dgn-np:NP466488.RApBCcS-BzE_HBD-gXWl91-x8b_uGYXHVRt5xRivB4QNU130_provenance a np:Provenance .
  
  dgn-np:NP466488.RApBCcS-BzE_HBD-gXWl91-x8b_uGYXHVRt5xRivB4QNU130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP466488.RApBCcS-BzE_HBD-gXWl91-x8b_uGYXHVRt5xRivB4QNU130_assertion {
  miriam-gene:7965 a ncit:C16612 .
  
  lld:C0023418 a ncit:C7057 .
  
  dgn-gda:DGN0c74260106add7824778493bb84636ac sio:SIO_000628 miriam-gene:7965, lld:C0023418;
    a sio:SIO_001121 .
}

dgn-np:NP466488.RApBCcS-BzE_HBD-gXWl91-x8b_uGYXHVRt5xRivB4QNU130_provenance {
  dgn-np:NP466488.RApBCcS-BzE_HBD-gXWl91-x8b_uGYXHVRt5xRivB4QNU130_assertion dcterms:description
      "[Our results indicated that (1) the expression of TEL-FGFR3 but not DeltaHLH-TEL-FGFR3 resulted in efficient focus formation in NIH/3T3 cells and conferred interleukin 3 independence to Ba/F3 cells by a constitutive tyrosine kinase activity probably through oligomerization by the HLH domain of TEL; (2) although effector proteins including classical mitogen-activated protein kinase (MAPK), p38 MAPK, phosphatidylinositol 3-kinase (PI3-K), mammalian target or rapamycin (mTOR), signal transducer and activator of transcription 3 (STAT-3) and STAT-5 were activated in TEL-FGFR3 transformants, the growth of the transformants was inhibited by SU5402 (concentration that inhibits 50% [IC5)]=5 microM) and the PI3-K inhibitor, LY294002 (IC5)=10 microM) and wortmannin (IC50=5 microM), but not by U0126, SB203580, or rapamycin; and (3) injection of TEL-FGFR3 transformants induced lethal leukemia into syngeneic mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:15514005;
    prov:wasDerivedFrom dgn-void:befree-2016;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-2016 pav:importedOn "2016-02-19"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP466488.RApBCcS-BzE_HBD-gXWl91-x8b_uGYXHVRt5xRivB4QNU130_publicationInfo {
  this: dcterms:created "2016-05-13T12:45:16+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v4.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v4.0.0" .
}