@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAoxWH2HaOh-AmMSFnj3c0wU6T3PDpiqRtpdhDWIEtQhs> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAoxWH2HaOh-AmMSFnj3c0wU6T3PDpiqRtpdhDWIEtQhs#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix schem: <http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 occursIn: mesh:D003593 , mesh:D013183 , obo:CL_0000576 , obo:UBERON_0002048 , species:9606 ;
    rdf:object schem:Nitrogen%20oxides ;
    rdf:predicate belv:increases ;
    rdf:subject go:0042116 ;
    a rdf:Statement .
  sub:assertion rdfs:label "bp(GOBP:\"macrophage activation\") -> a(SCHEM:\"Nitrogen oxides\")" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_3 ;
    pav:version "20131211" .
  sub:_2 prov:value "Macrophages in COPD. Macrophages may play a pivotal role in COPD as they are activated by cigarette smoke extract and secrete many inflammatory proteins that may orchestrate the inflammatory process in COPD. Neutrophils may be attracted by IL-8, GRO-{alpha}, LTB4, MCP-1, and CD8+ lymphocytes by IP-10, Mig, and I-TAC. Release of elastolytic enzymes including MMPs and cathepsins causes elastolysis and release of TGF-{beta}1 and CTGF. Release of TGF-{alpha} activates EGFR, which stimulates mucus hypersecretion. Macrophages also generate ROS and NO, which together form peroxynitrite and may contribute to steroid resistance." ;
    prov:wasQuotedFrom pubmed:15602009 .
  sub:_3 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15602009 ;
    prov:wasDerivedFrom beldoc: , sub:_2 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:32:36.727+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}