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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAoewTTBsbzwNECTMzksFljbKNxsb2R8DbIp3erFDJzjE#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAoewTTBsbzwNECTMzksFljbKNxsb2R8DbIp3erFDJzjE#_3 http://www.w3.org/ns/prov#value . We present a DM1 mouse model with inducible and skeletal muscle-specific expression of large tracts of CTG repeats in the context of DMPK exon 15. These mice recapitulate many findings associated with DM1 skeletal muscle, such as CUG RNA foci with Muscleblind-like 1 (MBNL1) protein colocalization, misregulation of developmentally regulated alternative splicing events, myotonia, characteristic histological abnormalities, and increased CUGBP1 protein levels. Importantly, this DM1 mouse model recapitulates severe muscle wasting, which has not been reported in models in which depletion of MBNL1 is the main feature. http://www.tkuhn.ch/bel2nanopub/RAoewTTBsbzwNECTMzksFljbKNxsb2R8DbIp3erFDJzjE#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18272483 http://www.tkuhn.ch/bel2nanopub/RAoewTTBsbzwNECTMzksFljbKNxsb2R8DbIp3erFDJzjE#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAoewTTBsbzwNECTMzksFljbKNxsb2R8DbIp3erFDJzjE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18272483 http://www.tkuhn.ch/bel2nanopub/RAoewTTBsbzwNECTMzksFljbKNxsb2R8DbIp3erFDJzjE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAoewTTBsbzwNECTMzksFljbKNxsb2R8DbIp3erFDJzjE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAoewTTBsbzwNECTMzksFljbKNxsb2R8DbIp3erFDJzjE#_3 http://www.tkuhn.ch/bel2nanopub/RAoewTTBsbzwNECTMzksFljbKNxsb2R8DbIp3erFDJzjE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAoewTTBsbzwNECTMzksFljbKNxsb2R8DbIp3erFDJzjE http://purl.org/dc/terms/created 2014-07-03T14:30:52.653+02:00 http://www.tkuhn.ch/bel2nanopub/RAoewTTBsbzwNECTMzksFljbKNxsb2R8DbIp3erFDJzjE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAoewTTBsbzwNECTMzksFljbKNxsb2R8DbIp3erFDJzjE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234