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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAo_V0JQpPU6rEXZCwf3O1Ymf0FczlsFA-pkSscfMw8_g#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAo_V0JQpPU6rEXZCwf3O1Ymf0FczlsFA-pkSscfMw8_g#_3 http://www.w3.org/ns/prov#value The aim of this study was to examine the effects of adiponectin on the progression of NASH to cirrhosis and tumor formation using adiponectin-knockout (KO) mice. METHODS: Using a choline-deficient L-amino acid-defined (CDAA) diet-induced mouse NASH model, liver histology and oxidative stress markers were investigated in KO and wild-type (WT) mice. RESULTS: Hepatic steatosis was enhanced to a greater extent in KO mice, compared to WT mice after a 1-week CDAA diet. After 24 weeks, 6 out of 14 KO mice developed liver cirrhosis and hepatic tumors, whereas the 15 WT mice showed only simple steatosis. In KO mice, hepatic cytochrome P450 2E1 levels were upregulated, and markers of oxidative stress (thiobarbituric acid reactive substances, 8-hydroxydeoxyguanosine-positive cells) were significantly increased compared with WT mice. http://www.tkuhn.ch/bel2nanopub/RAo_V0JQpPU6rEXZCwf3O1Ymf0FczlsFA-pkSscfMw8_g#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17459514 http://www.tkuhn.ch/bel2nanopub/RAo_V0JQpPU6rEXZCwf3O1Ymf0FczlsFA-pkSscfMw8_g#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAo_V0JQpPU6rEXZCwf3O1Ymf0FczlsFA-pkSscfMw8_g#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17459514 http://www.tkuhn.ch/bel2nanopub/RAo_V0JQpPU6rEXZCwf3O1Ymf0FczlsFA-pkSscfMw8_g#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAo_V0JQpPU6rEXZCwf3O1Ymf0FczlsFA-pkSscfMw8_g#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAo_V0JQpPU6rEXZCwf3O1Ymf0FczlsFA-pkSscfMw8_g#_3 http://www.tkuhn.ch/bel2nanopub/RAo_V0JQpPU6rEXZCwf3O1Ymf0FczlsFA-pkSscfMw8_g#pubinfo http://www.tkuhn.ch/bel2nanopub/RAo_V0JQpPU6rEXZCwf3O1Ymf0FczlsFA-pkSscfMw8_g http://purl.org/dc/terms/created 2014-07-03T14:33:10.179+02:00 http://www.tkuhn.ch/bel2nanopub/RAo_V0JQpPU6rEXZCwf3O1Ymf0FczlsFA-pkSscfMw8_g http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAo_V0JQpPU6rEXZCwf3O1Ymf0FczlsFA-pkSscfMw8_g http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234