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[Consequently, we assessed the methylation status of CDKN2A/p16, MGMT, MLH1 and p14(ARF) in adenomas arising in the Lynch syndrome, a familial colon cancer syndrome caused by MLH1 and MSH2 mutations, to determine if DNA methylation is a second hit mechanism in CRC and to characterize the role of DNA methylation in the polyp phase of the Lynch syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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