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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAntnb0skKUY-51fneHZNiszgsmnAsynS6eswlSEWutD8#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAntnb0skKUY-51fneHZNiszgsmnAsynS6eswlSEWutD8#_5 http://www.w3.org/ns/prov#value A G protein-coupled chemoattractant receptor (R) activates PI3K isoforms, which converts PtdIns(4,5)P2 to PtdIns(3,4,5)P3. PI3K activation itself would lead only to a transient increase in PtdIns(3,4,5)P3 followed by a decrease in this lipid product as a result of depletion of the upstream phosphoinositide substrates, such as PtdIns(4,5)P2. 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