http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#Head http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#assertion http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#provenance http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#assertion http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_2 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_3 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5465 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6125 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_4 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_4 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_1 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#assertion http://www.w3.org/2000/01/rdf-schema#label complex(p(HGNC:IGF1R),p(HGNC:IRS1)) -> kin(complex(SCOMP:"p85/p110 PI3Kinase Complex")) http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_6 http://www.w3.org/ns/prov#value Ligand binding to the extracellular subunits leads to activation of the intrinsic tyrosine kinases of the transmembrane subunits. The ATP-binding site at Lys1003 and the tyrosine kinase domain are required for all functions of the IGF-IR. Trans-phosphorylation between the subunits involves Tyr1131, 1135 and 1136 in the kinase domain and leads to full activation of kinase activity. Other tyrosine phosphorylated sites serve to recruit specific adaptor molecules via their SH2-binding domains. Phosphorylated Tyr950 in the juxtamembrane region serves as a docking site for the adaptor molecules insulin receptor substrate (IRS)-1 and Shc which are involved in activation of the phosphatidylinositol-3 kinase (PI3K) and MAPK/ERK kinase(MEK)-extracellular-regulated kinase (ERK)signaling pathways, respectively http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16621671 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16621671 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#_6 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA http://purl.org/dc/terms/created 2014-07-03T14:32:59.820+02:00 http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAnfL9-DhVvV1f_QOCTy_hQgG9TXu3jEOHMdkDHBjSPwA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234