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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAnSN-G35O21lcAwv9cl9DZmQu9vKoW_DL7bxKzsGviuM#_3 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAnSN-G35O21lcAwv9cl9DZmQu9vKoW_DL7bxKzsGviuM#_2 http://www.w3.org/ns/prov#value Normal leptin receptor, but not the mutated form present in fa/fa rats, has been shown to lead to changes in PDE2 expression and activity in brown fat [99]. Therefore, regulation of PDE isoforms by leptin is apparent in various tissues and further work will help understand the mechanism and consequences of this action. There are several other signalling proteins regulated by leptin that should be mentioned here. Two studies have demonstrated an ability of leptin to increase production of reactive oxygen species (ROS) in human umbilical vein endothelial cells (HUVEC) or bovine aortic endothelial cells (BAEC) [65,119]. http://www.tkuhn.ch/bel2nanopub/RAnSN-G35O21lcAwv9cl9DZmQu9vKoW_DL7bxKzsGviuM#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12020765 http://www.tkuhn.ch/bel2nanopub/RAnSN-G35O21lcAwv9cl9DZmQu9vKoW_DL7bxKzsGviuM#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAnSN-G35O21lcAwv9cl9DZmQu9vKoW_DL7bxKzsGviuM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12020765 http://www.tkuhn.ch/bel2nanopub/RAnSN-G35O21lcAwv9cl9DZmQu9vKoW_DL7bxKzsGviuM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAnSN-G35O21lcAwv9cl9DZmQu9vKoW_DL7bxKzsGviuM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAnSN-G35O21lcAwv9cl9DZmQu9vKoW_DL7bxKzsGviuM#_2 http://www.tkuhn.ch/bel2nanopub/RAnSN-G35O21lcAwv9cl9DZmQu9vKoW_DL7bxKzsGviuM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAnSN-G35O21lcAwv9cl9DZmQu9vKoW_DL7bxKzsGviuM http://purl.org/dc/terms/created 2014-07-03T14:31:49.247+02:00 http://www.tkuhn.ch/bel2nanopub/RAnSN-G35O21lcAwv9cl9DZmQu9vKoW_DL7bxKzsGviuM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAnSN-G35O21lcAwv9cl9DZmQu9vKoW_DL7bxKzsGviuM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234