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[Our data indicate that (i) the replication defect can be recovered in vivo by mutations in the env gene, without an associated pathogenic phenotype, and (ii) nef can function in the HXB/LW clone as a pathogenic factor that does not enhance HIV-1 replication in the thymus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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