@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP225428.RAnLbKy_EWDBMzgwW6QapaXLbWYfo4qzZhmfPTlpFYz0A> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP225428.RAnLbKy_EWDBMzgwW6QapaXLbWYfo4qzZhmfPTlpFYz0A130_head {
  this: np:hasAssertion dgn-np:NP225428.RAnLbKy_EWDBMzgwW6QapaXLbWYfo4qzZhmfPTlpFYz0A130_assertion;
    np:hasProvenance dgn-np:NP225428.RAnLbKy_EWDBMzgwW6QapaXLbWYfo4qzZhmfPTlpFYz0A130_provenance;
    np:hasPublicationInfo dgn-np:NP225428.RAnLbKy_EWDBMzgwW6QapaXLbWYfo4qzZhmfPTlpFYz0A130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP225428.RAnLbKy_EWDBMzgwW6QapaXLbWYfo4qzZhmfPTlpFYz0A130_assertion a np:Assertion .
  
  dgn-np:NP225428.RAnLbKy_EWDBMzgwW6QapaXLbWYfo4qzZhmfPTlpFYz0A130_provenance a np:Provenance .
  
  dgn-np:NP225428.RAnLbKy_EWDBMzgwW6QapaXLbWYfo4qzZhmfPTlpFYz0A130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP225428.RAnLbKy_EWDBMzgwW6QapaXLbWYfo4qzZhmfPTlpFYz0A130_assertion {
  miriam-gene:3123 a ncit:C16612 .
  
  lld:C0854359 a ncit:C7057 .
  
  dgn-gda:DGN9c02251bfc7d403b22fb739303b26b5d sio:SIO_000628 miriam-gene:3123, lld:C0854359;
    a sio:SIO_001121 .
}

dgn-np:NP225428.RAnLbKy_EWDBMzgwW6QapaXLbWYfo4qzZhmfPTlpFYz0A130_provenance {
  dgn-np:NP225428.RAnLbKy_EWDBMzgwW6QapaXLbWYfo4qzZhmfPTlpFYz0A130_assertion dcterms:description
      "[We analyzed structural motifs of peptides bound to HLA-DR4 (DRB1*0405 and DRB1*0406) and DR9 (DRB1*0901) and found that: (a) AxxBxC motif where A, B, and C are hydrophobic, hydrophobic, and neutral, respectively, is important for binding to DR4; (b) Gln (Q) or Ser at position C allow high-affinity binding specific to DRB1*0406 which is strongly associated with insulin autoimmune syndrome; (c) among human insulin-derived peptide fragments, the TSICSLYQLE of the human insulin alpha chain, which is exposed only under reducing conditions, has the highest affinity specific to DRB1*0406 by binding with the IxxLxQ motif; (d) a short-term human insulin-specific T cell line recognizes a peptide fragment containing the IxxLxQ motif as a major T cell epitope; and (e) in the AxxB motif, where A and B need to be hydrophobic for binding to DR9, neutral Ser is exceptionally allowed at position B.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:9119530;
    prov:wasDerivedFrom dgn-void:befree-20140225;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP225428.RAnLbKy_EWDBMzgwW6QapaXLbWYfo4qzZhmfPTlpFYz0A130_publicationInfo {
  this: dcterms:created "2014-10-02T12:34:05+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v2.1.0.0" .
  
  dgn-void:disgenetrdf pav:version "v2.1.0" .
}