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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAnLJrg1zICE6CX1iju61t_EYu6yrdKMicEFHLtzTQsiw#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAnLJrg1zICE6CX1iju61t_EYu6yrdKMicEFHLtzTQsiw#_3 http://www.w3.org/ns/prov#value The two plasminogen activators are mainly different in the structural determinants located in the noncatalytic regions of the proteins that are responsible for the enzyme binding to various components of the cell surface and of the cell environment. Thus, in the noncatalytic N-terminal region of the tPA molecule there are two additional domains as compared to the uPA molecule: a finger-domain and the second kringle-domain, which are responsible for specific binding to fibrin [24]. Precise timing and location of adequate extracellular proteolysis is provided by multiple mechanisms among which the mechanisms regulating the expression of plasminogen activators and of their inhibitors are especially important. A wide spectrum of hormones, growth factors, and cell environment factors are involved in the regulation of expression of the genes of plasminogen activators and of their inhibitors. The expression of uPA is activated by various inflammatory factors: cytokines [25], growth factors [26], and tumor promotors, such as phorbol-12-myristate-13-acetate [27], whereas antiinflammatory agents, such as glucocorticoids, inhibit the expression of uPA [28]. http://www.tkuhn.ch/bel2nanopub/RAnLJrg1zICE6CX1iju61t_EYu6yrdKMicEFHLtzTQsiw#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11841347 http://www.tkuhn.ch/bel2nanopub/RAnLJrg1zICE6CX1iju61t_EYu6yrdKMicEFHLtzTQsiw#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAnLJrg1zICE6CX1iju61t_EYu6yrdKMicEFHLtzTQsiw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11841347 http://www.tkuhn.ch/bel2nanopub/RAnLJrg1zICE6CX1iju61t_EYu6yrdKMicEFHLtzTQsiw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAnLJrg1zICE6CX1iju61t_EYu6yrdKMicEFHLtzTQsiw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAnLJrg1zICE6CX1iju61t_EYu6yrdKMicEFHLtzTQsiw#_3 http://www.tkuhn.ch/bel2nanopub/RAnLJrg1zICE6CX1iju61t_EYu6yrdKMicEFHLtzTQsiw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAnLJrg1zICE6CX1iju61t_EYu6yrdKMicEFHLtzTQsiw http://purl.org/dc/terms/created 2014-07-03T14:31:46.929+02:00 http://www.tkuhn.ch/bel2nanopub/RAnLJrg1zICE6CX1iju61t_EYu6yrdKMicEFHLtzTQsiw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAnLJrg1zICE6CX1iju61t_EYu6yrdKMicEFHLtzTQsiw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234