sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_4 ;
    pav:version "20131211" .
  sub:_3 prov:value "The two plasminogen activators are mainly different in the structural determinants located in the noncatalytic regions of the proteins that are responsible for the enzyme binding to various components of the cell surface and of the cell environment. Thus, in the noncatalytic N-terminal region of the tPA molecule there are two additional domains as compared to the uPA molecule: a finger-domain and the second kringle-domain, which are responsible for specific binding to fibrin [24].  Precise timing and location of adequate extracellular proteolysis is provided by multiple mechanisms among which the mechanisms regulating the expression of plasminogen activators and of their inhibitors are especially important. A wide spectrum of hormones, growth factors, and cell environment factors are involved in the regulation of expression of the genes of plasminogen activators and of their inhibitors. The expression of uPA is activated by various inflammatory factors: cytokines [25], growth factors [26], and tumor promotors, such as phorbol-12-myristate-13-acetate [27], whereas antiinflammatory agents, such as glucocorticoids, inhibit the expression of uPA [28]." ;
    prov:wasQuotedFrom pubmed:11841347 .
  sub:_4 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11841347 ;
    prov:wasDerivedFrom beldoc: , sub:_3 .
}