. . . . . . . . . . . . "p(HGNC:BCL2L11) -> bp(MESHPP:Apoptosis)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "The forkhead box class O (FOXO) transcription factors family members, FOXO1a and FOXO3a, are phosphorylated in an AKT-dependent manner in SCF-stimulated BMMCs [76]. FOXO3a phosphorylation leads to its proteosomal degradation following ubiquitination thereby blocking its transcriptional control of the pro-apopototic factor, Bim. SCF also induces the AKT- and MAPK-dependent phosphorylation of Bim in mouse bone marrow-derived mast cells and it has been proposed that this also leads to its proteosomal degradation [76]. Thus these observations would account for the ablity of PI3K-AKT driven pathways to promote mast cell survival." . . "Selventa" . . . . "2014-07-03T14:33:25.087+02:00"^^ . . .