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[Contrasting with this protective role, however, Nrf2 function may be potentially fatal in smoking-related lung tumorigenesis: as concluded from recent clinical investigations, lung tumor tissues harbor increased mutation or, alternatively, aberrant expression rates in either the KEAP1 or the NRF2 gene, generally resulting in constitutive Nrf2 activation, suggesting that abuse of Nrf2 function is an advantageous strategy of the (developing) tumor to protect itself against oxidative stress in general.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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