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[The included studies differed in terms of CFTR gene replacement agent and study design, which limited the meta-analysis.Although the first Moss study reported a significant improvement in respiratory function (forced expiratory volume at one second) 30 days after participants had received their first dose of gene therapy agent, this finding was not confirmed in their larger second study or in our meta-analysis.In participants who received the CFTR gene transfer agents in the Alton study, 'influenza-like' symptoms were found (risk ratio 7.00 (95% confidence interval 1.10 to 44.61)).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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