@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP1150110.RAn3L8Gq8gEqldBWhhTnQKVJKkoBbQJkH0GCWnGjYS6G8> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v4.0.0/void/> .

dgn-np:NP1150110.RAn3L8Gq8gEqldBWhhTnQKVJKkoBbQJkH0GCWnGjYS6G8130_head {
  this: np:hasAssertion dgn-np:NP1150110.RAn3L8Gq8gEqldBWhhTnQKVJKkoBbQJkH0GCWnGjYS6G8130_assertion;
    np:hasProvenance dgn-np:NP1150110.RAn3L8Gq8gEqldBWhhTnQKVJKkoBbQJkH0GCWnGjYS6G8130_provenance;
    np:hasPublicationInfo dgn-np:NP1150110.RAn3L8Gq8gEqldBWhhTnQKVJKkoBbQJkH0GCWnGjYS6G8130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP1150110.RAn3L8Gq8gEqldBWhhTnQKVJKkoBbQJkH0GCWnGjYS6G8130_assertion a np:Assertion .
  
  dgn-np:NP1150110.RAn3L8Gq8gEqldBWhhTnQKVJKkoBbQJkH0GCWnGjYS6G8130_provenance a np:Provenance .
  
  dgn-np:NP1150110.RAn3L8Gq8gEqldBWhhTnQKVJKkoBbQJkH0GCWnGjYS6G8130_publicationInfo
    a np:PublicationInfo .
}

dgn-np:NP1150110.RAn3L8Gq8gEqldBWhhTnQKVJKkoBbQJkH0GCWnGjYS6G8130_assertion {
  miriam-gene:7070 a ncit:C16612 .
  
  lld:C0002395 a ncit:C7057 .
  
  dgn-gda:DGN21c96d1fdef7e8619a27b98b01240741 sio:SIO_000628 miriam-gene:7070, lld:C0002395;
    a sio:SIO_001121 .
}

dgn-np:NP1150110.RAn3L8Gq8gEqldBWhhTnQKVJKkoBbQJkH0GCWnGjYS6G8130_provenance {
  dgn-np:NP1150110.RAn3L8Gq8gEqldBWhhTnQKVJKkoBbQJkH0GCWnGjYS6G8130_assertion dcterms:description
      "[The role of ER Ca(2+) release channels, the ryanodine receptors (RyanRs), has been extensivelys tudied in AD models and RyanR expression and activity are upregulated in the brains of various familial AD (FAD) models.The objective of this study was to utilize a genetic approach to evaluate the importance of RyanR type 3 (RyanR3) in the context of AD pathology.The expression of RyanR3 was also elevated in hippocampus of APPPS1 mice (Thy1-APPKM670/671NL, Thy1-PS1L166P).In young (≤ 3 mo) APPPS1 mice, the deletion of RyanR3 increased hippocampal neuronal network excitability and accelerated AD pathology, leading to mushroom spine loss and increased amyloid accumulation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:24476841;
    prov:wasDerivedFrom dgn-void:befree-2016;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-2016 pav:importedOn "2016-02-19"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP1150110.RAn3L8Gq8gEqldBWhhTnQKVJKkoBbQJkH0GCWnGjYS6G8130_publicationInfo {
  this: dcterms:created "2016-05-13T12:50:27+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v4.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v4.0.0" .
}