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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAmqL6Q99PISk6A2-S_IKUNM9RQlyBQ-ruOBRiWmyjw6Y#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAmqL6Q99PISk6A2-S_IKUNM9RQlyBQ-ruOBRiWmyjw6Y#_6 http://www.w3.org/ns/prov#value Neutrophils contain a soluble guanine-nucleotidebinding protein, made up of two components with molecular masses of 23 and 26 kDa, that mediates stimulation of phospholipase C-beta2 (PLCbeta2). We have identified the two components of the stimulatory heterodimer by amino acid sequencing as a Rho GTPase and the Rho guanine nucleotide dissociation inhibitor LyGDI. Using recombinant Rho GTPases and LyGDI, we demonstrate that PLCbeta2 is stimulated by guanosine 5'-O-(3-thiotriphosphate) (GTP[S])-activated Cdc42HsxLyGDI, but not by RhoAxLyGDI. Stimulation of PLCbeta2, which was also observed for GTP[S]-activated recombinant Rac1, was independent of LyGDI, but required C-terminal processing of Cdc42Hs/Rac1. Cdc42Hs/Rac1 also stimulated PLCbeta2 in a system made up of purified recombinant proteins, suggesting that this function is mediated by direct protein-protein interaction. http://www.tkuhn.ch/bel2nanopub/RAmqL6Q99PISk6A2-S_IKUNM9RQlyBQ-ruOBRiWmyjw6Y#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9799233 http://www.tkuhn.ch/bel2nanopub/RAmqL6Q99PISk6A2-S_IKUNM9RQlyBQ-ruOBRiWmyjw6Y#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAmqL6Q99PISk6A2-S_IKUNM9RQlyBQ-ruOBRiWmyjw6Y#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9799233 http://www.tkuhn.ch/bel2nanopub/RAmqL6Q99PISk6A2-S_IKUNM9RQlyBQ-ruOBRiWmyjw6Y#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAmqL6Q99PISk6A2-S_IKUNM9RQlyBQ-ruOBRiWmyjw6Y#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAmqL6Q99PISk6A2-S_IKUNM9RQlyBQ-ruOBRiWmyjw6Y#_6 http://www.tkuhn.ch/bel2nanopub/RAmqL6Q99PISk6A2-S_IKUNM9RQlyBQ-ruOBRiWmyjw6Y#pubinfo http://www.tkuhn.ch/bel2nanopub/RAmqL6Q99PISk6A2-S_IKUNM9RQlyBQ-ruOBRiWmyjw6Y http://purl.org/dc/terms/created 2014-07-03T14:34:17.403+02:00 http://www.tkuhn.ch/bel2nanopub/RAmqL6Q99PISk6A2-S_IKUNM9RQlyBQ-ruOBRiWmyjw6Y http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAmqL6Q99PISk6A2-S_IKUNM9RQlyBQ-ruOBRiWmyjw6Y http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234