sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "20131211" .
  sub:_5 prov:value "PI3K regulates the mTORC1 pathway via the activation of AKT which directly phosphorylates the negative regulators of mTOR activation, TSC1 and TSC2 (tuberin), thereby inactivating its inhibitory activity. This allows mTOR activation resulting in the phosphorylation of p70 ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4E-binding protein1 (4E-BP1) [78,79]. These events lead to mTOR-dependent gene transcription that regulates cell growth, protein synthesis, and metabolism in response to a variety of environmental stimuli [80]." ;
    prov:wasQuotedFrom pubmed:18775670 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:18775670 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}