@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP577933.RAmSJlS5ahO-pgjMGnSEjQpiHHdTJL58a0n8ynQRX-nFs> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v3.0.0/void/> .

dgn-np:NP577933.RAmSJlS5ahO-pgjMGnSEjQpiHHdTJL58a0n8ynQRX-nFs130_head {
  this: np:hasAssertion dgn-np:NP577933.RAmSJlS5ahO-pgjMGnSEjQpiHHdTJL58a0n8ynQRX-nFs130_assertion;
    np:hasProvenance dgn-np:NP577933.RAmSJlS5ahO-pgjMGnSEjQpiHHdTJL58a0n8ynQRX-nFs130_provenance;
    np:hasPublicationInfo dgn-np:NP577933.RAmSJlS5ahO-pgjMGnSEjQpiHHdTJL58a0n8ynQRX-nFs130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP577933.RAmSJlS5ahO-pgjMGnSEjQpiHHdTJL58a0n8ynQRX-nFs130_assertion a np:Assertion .
  
  dgn-np:NP577933.RAmSJlS5ahO-pgjMGnSEjQpiHHdTJL58a0n8ynQRX-nFs130_provenance a np:Provenance .
  
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      np:PublicationInfo .
}

dgn-np:NP577933.RAmSJlS5ahO-pgjMGnSEjQpiHHdTJL58a0n8ynQRX-nFs130_assertion {
  miriam-gene:4580 a ncit:C16612 .
  
  lld:C0023418 a ncit:C7057 .
  
  dgn-gda:DGNd3b8f2198f0e3354b5dd9c5341df20e9 sio:SIO_000628 miriam-gene:4580, lld:C0023418;
    a sio:SIO_001121 .
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dgn-np:NP577933.RAmSJlS5ahO-pgjMGnSEjQpiHHdTJL58a0n8ynQRX-nFs130_provenance {
  dgn-np:NP577933.RAmSJlS5ahO-pgjMGnSEjQpiHHdTJL58a0n8ynQRX-nFs130_assertion dcterms:description
      "[The human leukemia cell lines NALM6 (B-lineage) and CCRF/CEM (T-lineage) were used to assess potential mechanisms for these lineage differences in MTX accumulation, revealing i) greater total and long-chain MTXPG accumulation in NALM6 over a wide range of methotrexate concentrations (0.2-100 microM), ii) saturation of MTXPG accumulation in both cell lines, with a higher maximum (Emax in NALM6, iii) 3-fold higher constitutive FPGS mRNA expression and enzyme activity in NALM6 cells, iv) 2-fold lower levels of DHFR mRNA and protein in NALM6 cells, and v) 4-6 fold lower extracellular MTX concentration and 2-fold lower intracellular MTXPG concentration to produce equivalent cytotoxicity (LC50) in NALM6 versus CEM.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:9224825;
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  dgn-void:befree-20150227 pav:importedOn "2015-02-27"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP577933.RAmSJlS5ahO-pgjMGnSEjQpiHHdTJL58a0n8ynQRX-nFs130_publicationInfo {
  this: dcterms:created "2015-08-25T14:43:24+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
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