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[CSF biomarkers are largely consistent with disease trajectories predicted by ?-amyloid cascade (Hardy, J Alzheimer's Dis 2006;9(Suppl 3):151-3) and tau-mediated neurodegeneration hypotheses for AD, whereas brain atrophy and hypometabolism levels show predicted patterns but exhibit differing rates of change depending on region and disease severity; (3) the assessment of alternative methods of diagnostic categorization.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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