http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_head http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_assertion http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_provenance http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_publicationInfo http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Assertion http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_provenance http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Provenance http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_publicationInfo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#PublicationInfo http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_assertion http://identifiers.org/ncbigene/338 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612 http://linkedlifedata.com/resource/umls/id/C3272363 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057 http://rdf.disgenet.org/resource/gda/DGNf910dc1e17139d0919f293a3ba6573ac http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/338 http://rdf.disgenet.org/resource/gda/DGNf910dc1e17139d0919f293a3ba6573ac http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C3272363 http://rdf.disgenet.org/resource/gda/DGNf910dc1e17139d0919f293a3ba6573ac http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001122 http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_provenance http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_assertion http://purl.org/dc/terms/description [The studies can be summarized as follows: (1) apolipoprotein B predicts ischemic cardiovascular events in both genders, and is better than LDL cholesterol in this respect; (2) linkage disequilibrium structure in APOB is more complex than expected from HapMap data, because a minimal set of tag single nucleotide polymorphisms capturing the entire variation in APOB cannot be identified, and thus most polymorphisms must be evaluated separately in association studies; (3) APOB mutations and polymorphisms are associated with a range of apolipoprotein B and LDL cholesterol levels, although the magnitude of effect sizes of common polymorphisms are modest; (4) both mutations and polymorphisms are associated with LDL metabolism in vivo; (5) association of APOB mutations and polymorphisms with lipid and disease phenotype cannot be predicted in silico using evolutionary conservation or existing prediction programs; and finally, (6) except for the E4154K polymorphism that possibly predicts a reduction in risk of ischemic cerebrovascular disease and ischemic stroke, common APOB polymorphisms with modest effect sizes on lipid levels do not predict risk of ischemic heart disease, myocardial infarction, ischemic cerebrovascular disease, or ischemic stroke in the general population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/19200547 http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v4.0.0/void/befree-2016 http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/ECO_0000203 http://rdf.disgenet.org/v4.0.0/void/befree-2016 http://purl.org/pav/importedOn 2016-02-19 http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/ECO_0000212 http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk130_publicationInfo http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://purl.org/dc/terms/created 2016-05-13T12:47:11+02:00 http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v4.0.0/void/IBIGroup http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v4.0.0/void/disgenetv3.0rdf http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://purl.org/pav/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://purl.org/pav/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://purl.org/pav/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://purl.org/pav/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://purl.org/pav/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://purl.org/pav/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP719213.RAlrcz1hG37rCoKNhtaT3xiC9whVbxzfCLBaJ1jmqw9Dk http://purl.org/pav/version v4.0.0.0 http://rdf.disgenet.org/v4.0.0/void/disgenetv3.0rdf http://purl.org/pav/version v4.0.0