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[Gene expression analysis from bone metastases at day 55 revealed that tumor-produced integrins (?v?5) as well as factors relevant for angiogenesis (?v?3, VEGF, PDGF), bone resorption (PTHrP and RANKL), extracellular matrix remodeling (collagen, CD44) and bone marrow microenvironment (CXCR4) were significantly reduced upon therapy with cilengitide.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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