. . . . . . . . . . . . . . . . "tscript(p(HGNC:NRF1)) => r(HGNC:EIF2S1)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "A striking feature of this element is its palindrome sequences and eight-base pair direct repeats. We have purified to near homogeneity a 66-68-kDa protein that binds to this region and have designated it alpha-PAL {Nrf1}. The alpha-PAL-binding site extends from -74 to -10. By methylation protection analysis and mobility shift assay, the alpha-PAL-binding site is shown to be two adjacent sites, one with high and one with lower affinity, which bind alpha-PAL in a noncooperative manner. When the high affinity binding site is cloned upstream of the adenovirus 2 core promoter, in vitro transcription is stimulated 2-3-fold. When linked to a CAT reporter gene, activity of the eIF-2 alpha {eif2s1} promoter shows an approximate 2-fold dependence on the alpha-PAL element {in a leukemia cell line}." . . "Selventa" . . . . "2014-07-03T14:33:43.048+02:00"^^ . . .