http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#Head http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#assertion http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#provenance http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#assertion http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_2 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_3 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4566 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11187 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_4 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_5 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0005525 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_5 http://purl.obolibrary.org/obo/RO_0002204 http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/RAS%20Family http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_6 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_4 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_1 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#assertion http://www.w3.org/2000/01/rdf-schema#label complex(p(HGNC:GRB2),p(HGNC:SOS1)) => gtp(p(SFAM:"RAS Family")) http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_8 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_7 http://www.w3.org/ns/prov#value Tyrosine phosphorylation led to the association of BCR with the RAS guanine nucleotide exchange complex GRB2-SOS in vivo via the GRB2 SH2 domain, linking BCR to RAS signaling (Maru, Y., Peters, K. L., Afar, D. E. H., Shibuya, M., Witte, O. N., and Smithgall, T. E. (1995) Mol. Cell. Biol. 15, 835-842). In the present study, we demonstrate that BCR Tyr-246 and at least one of the closely spaced tyrosine residues, Tyr-279, Tyr-283, and Tyr-289 (3Y cluster), are phosphorylated by FES both in vitro and in 32Pi-labeled cells. Mutagenesis of BCR Tyr-177 to Phe completely abolished FES-induced BCR binding to the GRB2 SH2 domain, identifying Tyr-177 as an additional phosphorylation site for FES. http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/8955135 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/8955135 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#_7 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc http://purl.org/dc/terms/created 2014-07-03T14:33:55.446+02:00 http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAle0BlmsEdzrE15pADgoIghNdYcIg6bNPf6D4pUdzuMc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234