sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_7 ; pav:version "20131211" . sub:_6prov:value "Both uPA itself and uPA-generated plasmin can activate the latent matrix metalloproteinases and elastase [46, 148], which are responsible for the subsequent degradation of the extracellular matrix, during the endothelial cell migration and invasion. Moreover these two proteases activate virtually all growth factors involved in angiogenesis [42-45, 147, 149]. Hypoxia has been shown to increase the expression of angiogenic growth factors, but uPA and plasmin are required to provide proteolytic activation of the latent forms or release of matrix-bound growth factors." ; prov:wasQuotedFrompubmed:11841347 . sub:_7rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:11841347 ; prov:wasDerivedFrombeldoc: , sub:_6 . }