@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAlTJhI1LLHFQcoZiDEnpbTndxXQBHHbfxYeEp4vHBOTA> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAlTJhI1LLHFQcoZiDEnpbTndxXQBHHbfxYeEp4vHBOTA#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix scomp: <http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  scomp:p85%2Fp110%20PI3Kinase%20Complex a ProteinComplex: .
  
  sub:_1 hasAgent: sub:_2;
    a go:0005525 .
  
  sub:_2 geneProductOf: hgnc:5173;
    a Protein: .
  
  sub:_3 hasAgent: scomp:p85%2Fp110%20PI3Kinase%20Complex;
    a go:0016301 .
  
  sub:_4 occursIn: species:9606;
    rdf:object sub:_3;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "gtp(p(HGNC:HRAS)) -> kin(complex(SCOMP:\"p85/p110 PI3Kinase Complex\"))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "20131211" .
  
  sub:_5 prov:value "Elevated PLD activity, under most circumstances, does not lead to increased phosphorylation of Akt. Increased expression of PLD1 led to increased S6 kinase phosphorylation but did not increase Akt phosphorylation in rat fibroblasts (16). However, PLD1-induced increases in S6 kinase phosphorylation were blocked by the PI3K inhibitor LY294002 (16). Similarly, LY294002 suppressed S6 kinase phosphorylation in MDA-MB-231 cells, where there is elevated expression of PLD1 and elevated PLD activity (15). However, Tee et al. (9) were able to activate mTOR with exogenously supplied PA in the presence of the PI3K inhibitor wortmannin. PLD1-induced increases in S6 kinase phosphorylation were blocked by the PI3K inhibitor LY294002";
    prov:wasQuotedFrom pubmed:17210675 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:17210675;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:07.957+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}