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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAlRgJAHuxBAcfMkNpHIGJcbZhp6AWtIAaj6Hneq4ACnM#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAlRgJAHuxBAcfMkNpHIGJcbZhp6AWtIAaj6Hneq4ACnM#_4 http://www.w3.org/ns/prov#value We found that Bim–/– T cells had a global defect in cytokine production affecting all cytokines tested, which included IL-2, IL-4, IL-6, IL-10, IL-17A, and IFN-? (Figure 3). Consistent with these results, overexpression of Bim in EL-4 T cells significantly increased IL-2 production (Supplemental Figure 5). The defect in Bim–/– T cells appears to lie upstream of the cytokine synthesis because mRNA expression of selected cytokines (IL-2, IL-6, and IL-17A) was also significantly reduced in these cells (ELISA and QPCR) http://www.tkuhn.ch/bel2nanopub/RAlRgJAHuxBAcfMkNpHIGJcbZhp6AWtIAaj6Hneq4ACnM#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19411758 http://www.tkuhn.ch/bel2nanopub/RAlRgJAHuxBAcfMkNpHIGJcbZhp6AWtIAaj6Hneq4ACnM#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAlRgJAHuxBAcfMkNpHIGJcbZhp6AWtIAaj6Hneq4ACnM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19411758 http://www.tkuhn.ch/bel2nanopub/RAlRgJAHuxBAcfMkNpHIGJcbZhp6AWtIAaj6Hneq4ACnM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAlRgJAHuxBAcfMkNpHIGJcbZhp6AWtIAaj6Hneq4ACnM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAlRgJAHuxBAcfMkNpHIGJcbZhp6AWtIAaj6Hneq4ACnM#_4 http://www.tkuhn.ch/bel2nanopub/RAlRgJAHuxBAcfMkNpHIGJcbZhp6AWtIAaj6Hneq4ACnM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAlRgJAHuxBAcfMkNpHIGJcbZhp6AWtIAaj6Hneq4ACnM http://purl.org/dc/terms/created 2014-07-03T14:33:33.683+02:00 http://www.tkuhn.ch/bel2nanopub/RAlRgJAHuxBAcfMkNpHIGJcbZhp6AWtIAaj6Hneq4ACnM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAlRgJAHuxBAcfMkNpHIGJcbZhp6AWtIAaj6Hneq4ACnM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234