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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAlPfXFa-jyBwqZP--WEZw8a9VAWJ1_TY-vaC8VzEzOCs#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAlPfXFa-jyBwqZP--WEZw8a9VAWJ1_TY-vaC8VzEzOCs#_4 http://purl.org/dc/elements/1.1/identifier Entrez Gene Summary Human PON2 http://www.tkuhn.ch/bel2nanopub/RAlPfXFa-jyBwqZP--WEZw8a9VAWJ1_TY-vaC8VzEzOCs#_4 http://purl.org/dc/elements/1.1/title Entrez Gene Summary Human PON2 http://www.tkuhn.ch/bel2nanopub/RAlPfXFa-jyBwqZP--WEZw8a9VAWJ1_TY-vaC8VzEzOCs#_4 http://purl.org/dc/elements/1.1/type Online Resource http://www.tkuhn.ch/bel2nanopub/RAlPfXFa-jyBwqZP--WEZw8a9VAWJ1_TY-vaC8VzEzOCs#_5 http://www.w3.org/ns/prov#value Entrez Gene Summary Human: This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. 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