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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAlN1sPoIDTlUE10M0n-VCvaf_ey9h_V3rpm0FgYfyFxE#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAlN1sPoIDTlUE10M0n-VCvaf_ey9h_V3rpm0FgYfyFxE#_3 http://www.w3.org/ns/prov#value To study the functional consequences of RASSF1A expression in human cells, we made use of a tetracycline-inducible expression system (32) and the A549 lung cancer cell line, which is deficient in endogenous RASSF1A, p14Arf, and p16Ink4a expression (Supplementary Fig. S1A; ref. 35). In this model, addition of doxycycline induced transgenic expression of RASSF1A, which inhibited growth of lung cancer cells in vitro (Fig. 1A) and in vivo after s.c. transplantation into immunodeficient NOD/SCID mice (Fig. 1B). http://www.tkuhn.ch/bel2nanopub/RAlN1sPoIDTlUE10M0n-VCvaf_ey9h_V3rpm0FgYfyFxE#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19223555 http://www.tkuhn.ch/bel2nanopub/RAlN1sPoIDTlUE10M0n-VCvaf_ey9h_V3rpm0FgYfyFxE#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAlN1sPoIDTlUE10M0n-VCvaf_ey9h_V3rpm0FgYfyFxE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19223555 http://www.tkuhn.ch/bel2nanopub/RAlN1sPoIDTlUE10M0n-VCvaf_ey9h_V3rpm0FgYfyFxE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAlN1sPoIDTlUE10M0n-VCvaf_ey9h_V3rpm0FgYfyFxE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAlN1sPoIDTlUE10M0n-VCvaf_ey9h_V3rpm0FgYfyFxE#_3 http://www.tkuhn.ch/bel2nanopub/RAlN1sPoIDTlUE10M0n-VCvaf_ey9h_V3rpm0FgYfyFxE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAlN1sPoIDTlUE10M0n-VCvaf_ey9h_V3rpm0FgYfyFxE http://purl.org/dc/terms/created 2014-07-03T14:30:54.628+02:00 http://www.tkuhn.ch/bel2nanopub/RAlN1sPoIDTlUE10M0n-VCvaf_ey9h_V3rpm0FgYfyFxE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAlN1sPoIDTlUE10M0n-VCvaf_ey9h_V3rpm0FgYfyFxE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234