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http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#_8 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#_8 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#_7 http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#_8 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#_8 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#_1 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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#_10 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#_10 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#_9 http://www.w3.org/ns/prov#value Lysophosphatidic acid (LPA) induced mTOR was shown to be dependent on PLD1 and Rho (17). The activation of mTOR by Cdc42 was also dependent on PLD1 (18). Suppression of PLD1 expression blocked S6 kinase phosphorylation in B16 melanoma cells, and suppression of either PLD1 or mTOR led to melanogenesis in these cells (19). Very recently, it was reported that PLD2 forms a functional complex with mTOR and its binding partner Raptor (known as mTORC1) through a TOS (TOR signaling) motif in PLD2 (21). The interaction between mTORC1 and PLD2 was essential for mitogen stimulation of mTOR(21). Thus, in addition to the ability of PA to activate mTOR, there are several studies that have shown a PLD requirement for the activation of mTOR. http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#_9 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17210675 http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17210675 http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#_9 http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo http://purl.org/dc/terms/created 2014-07-03T14:33:07.958+02:00 http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAlGyvo4IF6F3HFRI0BHoGDeLzPmYsCNc9P-cJY49G9fo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234