sub:provenance {
beldoc: dce:description "Approximately 61,000 statements." ;
dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
dce:title "BEL Framework Large Corpus Document" ;
pav:authoredBy sub:_6 ;
pav:version "20131211" .
sub:_5 prov:value "From Fig. 4: Using the same time and dose strategies as before, a mean 6.2-fold induction of PLC{gamma} phosphorylation was observed following radiation treatment (Fig. 4). Increases in phosphorylation of Shc family members were observed following irradiation; the mean -fold changes (n = 3) were 2.3, 3.0, and 3.5 for the 66-, 52-, and 46-kDa isoforms, respectively. For both PLC{gamma} and Shc, EGF at 10 ng/ml induced a significantly greater increase in phosphorylation than IR (p < 0.05). Pretreatment of cells with 500 nM AG1478, a specific inhibitor of EGFR Tyr phosphorylation (29), abolished the radiation- and EGF-induced activation of both PLC{gamma} and Shc in A431 cells." ;
prov:wasQuotedFrom pubmed:15708852 .
sub:_6 rdfs:label "Selventa" .
sub:assertion prov:hadPrimarySource pubmed:15708852 ;
prov:wasDerivedFrom beldoc: ,
sub:_5 .
}