http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_head http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_assertion http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_provenance http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_publicationInfo http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Assertion http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_provenance http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Provenance http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_publicationInfo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#PublicationInfo http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_assertion http://identifiers.org/ncbigene/1269 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612 http://linkedlifedata.com/resource/umls/id/C0400966 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057 http://rdf.disgenet.org/gene-disease-association.ttl#DGNc93c7b68c3182120bfdcc91c31fa48f2 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/1269 http://rdf.disgenet.org/gene-disease-association.ttl#DGNc93c7b68c3182120bfdcc91c31fa48f2 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0400966 http://rdf.disgenet.org/gene-disease-association.ttl#DGNc93c7b68c3182120bfdcc91c31fa48f2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001121 http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_provenance http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_assertion http://purl.org/dc/terms/description [In particular, hepatoprotective properties for Cannabinoid Receptor type 2 (CB2) have been shown both through experimental murine models of liver injury and association study between a CB2 functional variant, Q63R, and liver enzymes in Italian obese children with steatosis.Here, in order to clarify the role of CB2 in severity of childhood NAFLD, we have investigated the association of the CB2 Q63R variant, with histological parameters of liver disease severity in 118 Italian children with histologically-proven NAFLD.CB2 Q63R genotype was assigned performing a TaqMan assay and a general linear model analysis was used to evaluate the association between the polymorphism and the histological parameters of liver damage.We have found that whereas CB2 Q63R variant is not associated with steatosis or fibrosis, it is associated with the severity of the inflammation (p = 0.002) and the presence of NASH (p = 0.02).Our findings suggest a critical role for CB2 Q63R variant in modulating hepatic inflammation state in obese children and in the consequent increased predisposition of these patients to liver damage.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/22927922 http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v2.1.0/void.ttl#befree-20140225 http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/eco.owl#ECO_0000203 http://rdf.disgenet.org/v2.1.0/void.ttl#befree-20140225 http://purl.org/pav/2.0/importedOn 2014-02-25 http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000212 http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k130_publicationInfo http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://purl.org/dc/terms/created 2014-10-02T12:35:45+02:00 http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v2.1.0/void.ttl#IBIGroup http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v2.1.0/void.ttl#disgenetrdf http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://purl.org/pav/2.0/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/nanopublications.trig#NP380804.RAl2-viobsQU2LuGgWggOoYnJ6--3Xwb80Alf7WE400-k http://purl.org/pav/2.0/version v2.1.0.0 http://rdf.disgenet.org/v2.1.0/void.ttl#disgenetrdf http://purl.org/pav/2.0/version v2.1.0