[ { "@graph" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI.assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI.provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI.pubinfo" } ] } ], "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI.Head" }, { "@graph" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._1", "@type" : [ "http://purl.org/obo/owl/SO#SO_0001148", "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition" ], "http://semanticscience.org/resource/SIO_000053" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._2" }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._3" } ], "http://www.w3.org/2000/01/rdf-schema#comment" : [ { "@value" : "No effect on endoproteolytic cleavage. No effect on APP nor NOTCH1 processing. Slightly increased Abeta42/Abeta40 ratio." } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._2", "@type" : [ "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition" ], "http://semanticscience.org/resource/SIO_000300" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "429" } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._3", "@type" : [ "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition" ], "http://semanticscience.org/resource/SIO_000300" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "429" } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._4", "@type" : [ "http://purl.org/obo/owl/SO#SO_0001148", "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition" ], "http://semanticscience.org/resource/SIO_000053" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._5" }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._6" } ], "http://www.w3.org/2000/01/rdf-schema#comment" : [ { "@value" : "No endoproteolytic cleavage; no APP nor NOTCH1 processing. No detectable Abetano detectable Abeta." } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._5", "@type" : [ "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition" ], "http://semanticscience.org/resource/SIO_000300" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "429" } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._6", "@type" : [ "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition" ], "http://semanticscience.org/resource/SIO_000300" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "429" } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._7", "@type" : [ "http://purl.org/obo/owl/SO#SO_0001148", "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition" ], "http://semanticscience.org/resource/SIO_000053" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._8" }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._9" } ], "http://www.w3.org/2000/01/rdf-schema#comment" : [ { "@value" : "Very little endoproteolysis. Little APP processing. No NOTCH1 processing. Very low levels Abeta40 and no detectable Abeta42." } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._8", "@type" : [ "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition" ], "http://semanticscience.org/resource/SIO_000300" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "429" } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._9", "@type" : [ "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition" ], "http://semanticscience.org/resource/SIO_000300" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "429" } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI.assertion", "http://www.w3.org/2000/01/rdf-schema#comment" : [ { "@value" : "Mutagenesis site occurs in NX_P49768-2 at amino acids 429 - 429." } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI.seqFeature", "@type" : [ "http://purl.org/obo/owl/SO#SO_000010" ], "http://purl.obolibrary.org/obo/#BFO_0000066" : [ { "@id" : "http://www.nextprot.org/db/search#NX_P49768-2" } ], "http://semanticscience.org/resource/SIO_000008" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._1" }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._4" }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._7" } ] } ], "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI.assertion" }, { "@graph" : [ { "@id" : "http://www.nextprot.org/help/quality_criteria/gold", "@type" : [ "http://purl.obolibrary.org/obo/eco.owl#ECO_0000205" ], "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "neXtProt gold" } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._10", "@type" : [ "http://www.bioassayontology.org/bao#BAO_0002095" ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._11", "@type" : [ "http://purl.obolibrary.org/obo/eco.owl#ECO_0000218" ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._12", "@type" : [ "http://www.bioassayontology.org/bao#BAO_0002095" ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._13", "@type" : [ "http://purl.obolibrary.org/obo/eco.owl#ECO_0000218" ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._14", "@type" : [ "http://www.bioassayontology.org/bao#BAO_0002095" ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._15", "@type" : [ "http://purl.obolibrary.org/obo/eco.owl#ECO_0000218" ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI.assertion", "@type" : [ "http://purl.obolibrary.org/obo/eco.owl#ECO_0000006", "http://purl.obolibrary.org/obo/eco.owl#ECO_0000200" ], "http://purl.org/net/provenance/ns#usedData" : [ { "@id" : "http://www.uniprot.org/uniprot/P49768" } ], "http://purl.org/ontology/wi/core#evidence" : [ { "@id" : "http://www.nextprot.org/help/quality_criteria/gold" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._10" }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._12" }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._14" } ], "http://www.w3.org/ns/prov#wasGeneratedBy" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._11" }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._13" }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._15" } ] } ], "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI.provenance" }, { "@graph" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-09-19T00:00:00.0Z" } ], "http://purl.org/dc/terms/rights" : [ { "@id" : "http://creativecommons.org/licenses/by/3.0/" } ], "http://purl.org/dc/terms/rightsHolder" : [ { "@id" : "http://nextprot.org" } ], "http://purl.org/net/provenance/ns#usedData" : [ { "@value" : "neXtProt database" } ], "http://swan.mindinformatics.org/ontologies/1.2/pav/authoredBy" : [ { "@value" : "CALIPHO project" }, { "@id" : "http://orcid.org/0000-0001-6710-1373" }, { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1303-2189" }, { "@id" : "http://orcid.org/0000-0003-1813-6857" } ], "http://swan.mindinformatics.org/ontologies/1.2/pav/versionNumber" : [ { "@value" : "1" } ], "http://www.w3.org/ns/prov#wasGeneratedBy" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._16" }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._17" }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._18" } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._16", "@type" : [ "http://purl.obolibrary.org/obo/eco.owl#ECO_0000248" ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._17", "@type" : [ "http://purl.obolibrary.org/obo/eco.owl#ECO_0000248" ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI._18", "@type" : [ "http://purl.obolibrary.org/obo/eco.owl#ECO_0000248" ] } ], "@id" : "http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_429_429.RAktJ9DIU-zxCexYp102TfuJRWPFO-EcbLygAy1ogjjaI.pubinfo" } ]