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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAkiw9oWT4PAXomV2GQVzplW0eKQrif0KWptqLiDIGxBk#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAkiw9oWT4PAXomV2GQVzplW0eKQrif0KWptqLiDIGxBk#_4 http://www.w3.org/ns/prov#value The molecular basis for differential P450arom expression in endometriosis and eutopic endometrium stromal cells was studied. Two critical regulatory regions one being the -214/-100 bp (protein binding to a nuclear receptor half-site NRHS, AGGTCA) proximal region and the other a -517/ -214 (an imperfect cAMP response element TGCACGTCA) distal region was identified. COUP-TF (both isoform I and II) transcripts were present in both eutopic endometrial and endometriotic tissues, whereas SF-1 transcripts were detected in all endometriotic tissues. In addition a dose-dependent direct competition between SF-1 and COUP-TF for occupancy of the NRHS was seen, to which SF-1 bound with a higher affinity. Finally, overexpression of SF-1 in eutopic endometrial and endometriotic cells strikingly potentiated baseline and cAMP-induced activities of -517 promoter II construct, whereas overexpression of COUP-TF almost completely abolished these activities. Thus COUP-TF might be one of the factors responsible for the inhibition of P450arom expression in eutopic endometrial stromal cells, which lack SF-1 expression in the majority (80%) of the samples. http://www.tkuhn.ch/bel2nanopub/RAkiw9oWT4PAXomV2GQVzplW0eKQrif0KWptqLiDIGxBk#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9973254 http://www.tkuhn.ch/bel2nanopub/RAkiw9oWT4PAXomV2GQVzplW0eKQrif0KWptqLiDIGxBk#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAkiw9oWT4PAXomV2GQVzplW0eKQrif0KWptqLiDIGxBk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9973254 http://www.tkuhn.ch/bel2nanopub/RAkiw9oWT4PAXomV2GQVzplW0eKQrif0KWptqLiDIGxBk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAkiw9oWT4PAXomV2GQVzplW0eKQrif0KWptqLiDIGxBk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAkiw9oWT4PAXomV2GQVzplW0eKQrif0KWptqLiDIGxBk#_4 http://www.tkuhn.ch/bel2nanopub/RAkiw9oWT4PAXomV2GQVzplW0eKQrif0KWptqLiDIGxBk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAkiw9oWT4PAXomV2GQVzplW0eKQrif0KWptqLiDIGxBk http://purl.org/dc/terms/created 2014-07-03T14:34:21.728+02:00 http://www.tkuhn.ch/bel2nanopub/RAkiw9oWT4PAXomV2GQVzplW0eKQrif0KWptqLiDIGxBk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAkiw9oWT4PAXomV2GQVzplW0eKQrif0KWptqLiDIGxBk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234