sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_4 prov:value "The molecular basis for differential P450arom expression in endometriosis and eutopic endometrium stromal cells was studied. Two critical regulatory regions one being the -214/-100 bp (protein binding to a nuclear receptor half-site NRHS, AGGTCA) proximal region and the other a -517/ -214 (an imperfect cAMP response element TGCACGTCA) distal region was identified. COUP-TF (both isoform I and II) transcripts were present in both eutopic endometrial and endometriotic tissues, whereas SF-1 transcripts were detected in all endometriotic tissues. In addition a dose-dependent direct competition between SF-1 and COUP-TF for occupancy of the NRHS was seen, to which SF-1 bound with a higher affinity. Finally, overexpression of SF-1 in eutopic endometrial and endometriotic cells strikingly potentiated baseline and cAMP-induced activities of -517 promoter II construct, whereas overexpression of COUP-TF almost completely abolished these activities. Thus COUP-TF might be one of the factors responsible for the inhibition of P450arom expression in eutopic endometrial stromal cells, which lack SF-1 expression in the majority (80%) of the samples." ;
    prov:wasQuotedFrom pubmed:9973254 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:9973254 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}