http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_head http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_assertion http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_provenance http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_publicationInfo http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Assertion http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_provenance http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Provenance http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_publicationInfo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#PublicationInfo http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_assertion http://identifiers.org/ncbigene/611 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612 http://linkedlifedata.com/resource/umls/id/C0008497 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057 http://rdf.disgenet.org/resource/gda/DGNdbc1044508a299ea6b1eb25569e3ec18 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/611 http://rdf.disgenet.org/resource/gda/DGNdbc1044508a299ea6b1eb25569e3ec18 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0008497 http://rdf.disgenet.org/resource/gda/DGNdbc1044508a299ea6b1eb25569e3ec18 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001121 http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_provenance http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_assertion http://purl.org/dc/terms/description [Particularly interesting were the observations that: 1) despite their nearly identical sequences and close chromosomal proximity, the six beta CG genes are distinguished from one another within the same and different cell types by their extent and pattern of methylation; 2) the beta CG locus is significantly hypomethylated in placenta, a state maintained in choriocarcinoma cells (JAr); 3) the beta CG gene cluster is unmethylated at a limited set of sites in DNA from both 2RA (a transformed fibroblast cell line that does not produce beta-subunit) and CBT (a glioblastoma cell line that produces beta-subunit ectopically), suggesting that general demethylation of the domain does not accompany activation of the locus in CBT but rather that site-specific changes may be responsible, at least in part, for inappropriate beta CG expression; and 4) the ratio of beta CG gene 3 transcripts to beta CG gene 5 transcripts is at least 10-fold higher in CBT cells than in JAr cells, suggesting that the reduced methylation in CBT cells of gene 3 compared to gene 5 may be a factor contributing to the activity of these genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/7505395 http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v4.0.0/void/befree-2016 http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/ECO_0000203 http://rdf.disgenet.org/v4.0.0/void/befree-2016 http://purl.org/pav/importedOn 2016-02-19 http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/ECO_0000212 http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs130_publicationInfo http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://purl.org/dc/terms/created 2016-05-13T12:51:39+02:00 http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v4.0.0/void/IBIGroup http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v4.0.0/void/disgenetv3.0rdf http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://purl.org/pav/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://purl.org/pav/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://purl.org/pav/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://purl.org/pav/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://purl.org/pav/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://purl.org/pav/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP1309264.RAkijjWys3tl0HppvHM27rP33N0BLQj3HMzRgilDQ8xMs http://purl.org/pav/version v4.0.0.0 http://rdf.disgenet.org/v4.0.0/void/disgenetv3.0rdf http://purl.org/pav/version v4.0.0