http://rdf.disgenet.org/resource/nanopub/NP710587.RAkcazdsZzhhw4KhP2ewbi__5xBIXwhVwawzi3_F-KWLs
type: Nanopublication
created: 2016-05-13T12:47:07+02:00
rights: http://opendatacommons.org/licenses/odbl/1.0/
rights holder: IBIGroup
subject: SIO_000983
used data: disgenetv3.0rdf
authored by: http://orcid.org/0000-0001-5999-6269
authored by: http://orcid.org/0000-0002-7534-7661
authored by: 0000-0002-9383-528X
authored by: http://orcid.org/0000-0003-0169-8159
authored by: http://orcid.org/0000-0003-1244-7654
created by: http://orcid.org/0000-0003-0169-8159
version: v4.0.0.0

http://rdf.disgenet.org/resource/nanopub/NP710587.RAkcazdsZzhhw4KhP2ewbi__5xBIXwhVwawzi3_F-KWLs130_assertion
type: Assertion
description: [Livers retrieved 30 minutes after cardiac arrest of male Wistar rats (200-300 g) were preserved with histidine-tryptophan-ketoglutarate (HTK) solution for 18 hours by simple cold storage (CS) or subjected to short-term resuscitation (STR) with oxygenated (pO(2) > 500 mm Hg) machine perfusion with HTK at 4 degrees C, 12 degrees C, or 22 degrees C for 2 hours with subsequent CS for 16 hours at 4 degrees C. Upon reperfusion in a normothermic perfusion circuit, STR significantly improved enzyme leakage (alanine aminotransferase, glutamate dehydrogenase) and metabolic recovery (tissue levels of ATP) providing best values at 12 degrees C or 22 degrees C. Moreover, a hugely increased gene expression of the adhesion molecule ICAM-1 as well as major histocompatibility complex (MHC) class II antigen was seen after CS, but significantly alleviated by STR at 4 degrees C or 12 degrees C. However, mRNA for both surface proteins rose significantly after STR at 22 degrees C compared with CS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
evidence: DisGeNET evidence - LITERATURE
SIO_000772: http://identifiers.org/pubmed/19100381
was generated by: ECO_0000203

befree-2016
imported on: 2016-02-19

DisGeNET evidence - LITERATURE
type: ECO_0000212
comment: Gene-disease associations inferred from text-mining the literature.

disgenetv3.0rdf
version: v4.0.0