@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP42146.RAkXwCCMnAbZSATvEz8RM4L0EYRLAWJAnS7BzjrPqJ7nc> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v3.0.0/void/> .

dgn-np:NP42146.RAkXwCCMnAbZSATvEz8RM4L0EYRLAWJAnS7BzjrPqJ7nc130_head {
  this: np:hasAssertion dgn-np:NP42146.RAkXwCCMnAbZSATvEz8RM4L0EYRLAWJAnS7BzjrPqJ7nc130_assertion;
    np:hasProvenance dgn-np:NP42146.RAkXwCCMnAbZSATvEz8RM4L0EYRLAWJAnS7BzjrPqJ7nc130_provenance;
    np:hasPublicationInfo dgn-np:NP42146.RAkXwCCMnAbZSATvEz8RM4L0EYRLAWJAnS7BzjrPqJ7nc130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP42146.RAkXwCCMnAbZSATvEz8RM4L0EYRLAWJAnS7BzjrPqJ7nc130_assertion a np:Assertion .
  
  dgn-np:NP42146.RAkXwCCMnAbZSATvEz8RM4L0EYRLAWJAnS7BzjrPqJ7nc130_provenance a np:Provenance .
  
  dgn-np:NP42146.RAkXwCCMnAbZSATvEz8RM4L0EYRLAWJAnS7BzjrPqJ7nc130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP42146.RAkXwCCMnAbZSATvEz8RM4L0EYRLAWJAnS7BzjrPqJ7nc130_assertion {
  miriam-gene:177 a ncit:C16612 .
  
  lld:C0853897 a ncit:C7057 .
  
  dgn-gda:DGNa7c2f3abe59fca421c0c733e505c8dc1 sio:SIO_000628 miriam-gene:177, lld:C0853897;
    a sio:SIO_001120 .
}

dgn-np:NP42146.RAkXwCCMnAbZSATvEz8RM4L0EYRLAWJAnS7BzjrPqJ7nc130_provenance {
  dgn-np:NP42146.RAkXwCCMnAbZSATvEz8RM4L0EYRLAWJAnS7BzjrPqJ7nc130_assertion dcterms:description
      "[Rats with DCM showed declined systolic myocardial performance associated with myocardial hypertrophy and fibrosis, which were accompanied with metabolism abnormalities, aberrant myocardial enzymes, increased AGEs (advanced glycation end products) accumulation and RAGE (receptor for AGEs) expression, elevated markers of oxidative stress (MDA, SOD, the ratio of NADP(+)/NADPH, Rac1 activity, NADPH oxidase subunits expression of gp91(phox) and p47(phox) ), raised inflammatory factor (TNF-I+- and IL-1I2), enhanced apoptotic cell death (ratio of bax/bcl-2, caspase-3 activity and TUNEL), diminished Akt and GSK-3I2 phosphorylation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_predicted;
    sio:SIO_000772 miriam-pubmed:23251674;
    prov:wasDerivedFrom dgn-void:rgd-20150221;
    prov:wasGeneratedBy eco:ECO_0000218 .
  
  dgn-void:rgd-20150221 pav:importedOn "2015-02-21"^^xsd:date .
  
  dgn-void:source_evidence_predicted a eco:ECO_0000266;
    rdfs:comment "Gene-disease associations inferred from animal model manually asserted gene-disease associations."@en;
    rdfs:label "DisGeNET evidence - PREDICTED"@en .
}

dgn-np:NP42146.RAkXwCCMnAbZSATvEz8RM4L0EYRLAWJAnS7BzjrPqJ7nc130_publicationInfo {
  this: dcterms:created "2015-08-25T14:38:03+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v3.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v3.0.0" .
}