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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAkHu3bmh91_TmxnGKwqOLBt5Eo8f_x7AjF3zMq0IjX6c#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAkHu3bmh91_TmxnGKwqOLBt5Eo8f_x7AjF3zMq0IjX6c#_3 http://www.w3.org/ns/prov#value In the present study we generated F9 cells expressing doxycycline-inducible hepatocyte nuclear factor (HNF)-4alpha, a nuclear receptor. We herein show that induction of HNF-4alpha initiates differentiation of F9 cells to polarized epithelial cells, in which tight-junction proteins occludin, claudin-6, claudin-7, and ZO-1 are concentrated at the apical-most regions of lateral membranes. Expression of occludin, claudin-6, and claudin-7 was induced in the cells by doxycycline treatment in a dose- and time-dependent manner, in terms of the amount of HNF-4alpha. http://www.tkuhn.ch/bel2nanopub/RAkHu3bmh91_TmxnGKwqOLBt5Eo8f_x7AjF3zMq0IjX6c#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12749857 http://www.tkuhn.ch/bel2nanopub/RAkHu3bmh91_TmxnGKwqOLBt5Eo8f_x7AjF3zMq0IjX6c#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAkHu3bmh91_TmxnGKwqOLBt5Eo8f_x7AjF3zMq0IjX6c#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12749857 http://www.tkuhn.ch/bel2nanopub/RAkHu3bmh91_TmxnGKwqOLBt5Eo8f_x7AjF3zMq0IjX6c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAkHu3bmh91_TmxnGKwqOLBt5Eo8f_x7AjF3zMq0IjX6c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAkHu3bmh91_TmxnGKwqOLBt5Eo8f_x7AjF3zMq0IjX6c#_3 http://www.tkuhn.ch/bel2nanopub/RAkHu3bmh91_TmxnGKwqOLBt5Eo8f_x7AjF3zMq0IjX6c#pubinfo http://www.tkuhn.ch/bel2nanopub/RAkHu3bmh91_TmxnGKwqOLBt5Eo8f_x7AjF3zMq0IjX6c http://purl.org/dc/terms/created 2014-07-03T14:32:02.171+02:00 http://www.tkuhn.ch/bel2nanopub/RAkHu3bmh91_TmxnGKwqOLBt5Eo8f_x7AjF3zMq0IjX6c http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAkHu3bmh91_TmxnGKwqOLBt5Eo8f_x7AjF3zMq0IjX6c http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234