http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#Head http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#assertion http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#provenance http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#assertion http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_2 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=7029 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_3 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_4 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_3 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_5 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_4 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3431 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_5 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=8980 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_6 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CLO_0003659 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_6 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_3 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_1 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(HGNC:MET)) => complex(p(HGNC:ERBB3),p(HGNC:PIK3R2)) http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_8 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_7 http://www.w3.org/ns/prov#value To investigate how MET activates ERBB3 tyrosine phosphorylation, we first expressed ERBB3 alone or in combination with MET in Chinese hamster ovary (CHO) cells, which normally do not express detectable levels of EGFR, ERBB2, or ERBB3. Coexpression of MET and ERBB3 resulted in marked phosphorylation of ERBB3 (Fig. 3D). This phosphorylation could be blocked with PHA-665752 but not with high concentrations of gefitinib (3 mM), lapatinib (3 mM) or the SRC family kinase inhibitor PP2 (10 mM). In addition, phosphorylated ERBB3 coimmunoprecipitated with p85 in a MET kinase–dependent manner (fig. S6). http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17463250 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17463250 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#_7 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0 http://purl.org/dc/terms/created 2014-07-03T14:33:10.270+02:00 http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAk6bt8hksBVhMclw3uqSXfaqVtmq_3ECSnMJgvlA3jh0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234