http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE#head http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE http://www.nanopub.org/nschema#hasAssertion http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE#assertion http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE http://www.nanopub.org/nschema#hasProvenance http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE#provenance http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE http://www.nanopub.org/nschema#hasPublicationInfo http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE#publicationInfo http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE#assertion http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/bio2rdf_vocabulary:identifier DB00331 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/bio2rdf_vocabulary:namespace drugbank http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/bio2rdf_vocabulary:uri http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/bio2rdf_vocabulary:x-identifiers.org http://identifiers.org/drugbank/DB00331 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:drugbank-id APRD01099 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:drugbank-id DB00331 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-ahfs http://bio2rdf.org/ahfs:68:20.04 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-atc http://bio2rdf.org/atc:A10BD11 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-cas http://bio2rdf.org/cas:657-24-9 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-chebi http://bio2rdf.org/chebi:6801 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-chemspider http://bio2rdf.org/chemspider:3949 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-dpd http://bio2rdf.org/dpd:2265583 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-kegg http://bio2rdf.org/kegg:C07151 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-kegg http://bio2rdf.org/kegg:D04966 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-ndc http://bio2rdf.org/ndc:0781-5050-61 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-pharmgkb http://bio2rdf.org/pharmgkb:PA450395 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-pubchemcompound http://bio2rdf.org/pubchem.compound:4091 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-pubchemsubstance http://bio2rdf.org/pubchem.substance:46507752 http://bio2rdf.org/drugbank:DB00331 http://bio2rdf.org/drugbank_vocabulary:x-wikipedia http://bio2rdf.org/wikipedia:Metformin http://bio2rdf.org/drugbank:DB00331 http://purl.org/dc/terms/description Metformin is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM). It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption and increasing insulin-mediated glucose uptake. Metformin is the only oral antihyperglycemic agent that is not associated with weight gain. Metformin may induce weight loss and is the drug of choice for obese NIDDM patients. When used alone, metformin does not cause hypoglycemia; however, it may potentiate the hypoglycemic effects of sulfonylureas and insulin. Its main side effects are dyspepsia, nausea and diarrhea. Dose titration and/or use of smaller divided doses may decrease side effects. Metformin should be avoided in those with severely compromised renal function (creatinine clearance < 30 ml/min), acute/decompensated heart failure, severe liver disease and for 48 hours after the use of iodinated contrast dyes due to the risk of lactic acidosis. Lower doses should be used in the elderly and those with decreased renal function. Metformin decreases fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Metformin may also have a positive effect on lipid levels. In 2012, a combination tablet of linagliptin plus metformin hydrochloride was marketed under the name Jentadueto for use in patients when treatment with both linagliptin and metformin is appropriate. http://bio2rdf.org/drugbank:DB00331 http://purl.org/dc/terms/identifier drugbank:DB00331 http://bio2rdf.org/drugbank:DB00331 http://purl.org/dc/terms/title Metformin http://bio2rdf.org/drugbank:DB00331 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://bio2rdf.org/drugbank_vocabulary:Drug http://bio2rdf.org/drugbank:DB00331 http://www.w3.org/2000/01/rdf-schema#label Metformin [drugbank:DB00331] http://bio2rdf.org/drugbank:DB00331 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugbank.ca/drugs/DB00331 http://bio2rdf.org/drugbank:DB00331 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugs.com/metformin.html http://bio2rdf.org/drugbank:DB00331 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.rxlist.com/cgi/generic4/glumetza.htm http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE#provenance http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://bio2rdf.org/drugbank_resource:bio2rdf.dataset.drugbank.R3 http://www.w3.org/ns/dcat#distribution http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://purl.org/dc/terms/created 2015-01-09T17:00:50-05:00 http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://purl.org/pav/retrievedOn 2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.w3.org/ns/prov#wasAttributedTo http://drugbank.ca http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE#publicationInfo http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE#signature.MCwCFB1mbx9ySjb6 http://purl.org/nanopub/x/hasPublicKey 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 http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE#signature.MCwCFB1mbx9ySjb6 http://purl.org/nanopub/x/hasSignature MCwCFB1mbx9ySjb6aGHubdaIgLdZys+5AhR/YD+rffcht2s3CtRw0XnHv4yeYw== http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE#signature.MCwCFB1mbx9ySjb6 http://purl.org/nanopub/x/signedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE http://purl.org/dc/terms/created 2018-03-30T11:11:08.902+02:00 http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE http://purl.org/dc/terms/license https://creativecommons.org/licenses/by-nc/4.0/ http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE http://purl.org/nanopub/x/hasSignatureElement http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE#signature.MCwCFB1mbx9ySjb6 http://bio2rdf.org/drugbank:DB00331_nanopub.RAk6BL8cWYPTRLogknNE80iauvMYjJ8kLqo4B7BTPqwlE http://www.w3.org/ns/prov#wasGeneratedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#specializationOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://purl.org/dc/terms/identifier 7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#used https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasAssociatedWith https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasStartedBy http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/dc/terms/isVersionOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/pav/version eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234