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[Taken together, these results demonstrate the efficacy of combined inhibition of Wee1 and PARP inhibitors for radiosensitizing pancreatic cancers and support the model that Wee1 inhibition sensitizes cells to PARP inhibitor-mediated radiosensitization through inhibition of HRR and abrogation of the G2 checkpoint, ultimately resulting in unrepaired, lethal DNA damage and radiosensitization.Clin Cancer Res; 20(19); 5085-96.©2014 AACR.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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