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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAjfSP_1GoUC4kmGsYZuUU1dVuD3s0h5DCozKtRuFxYWI#_8 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAjfSP_1GoUC4kmGsYZuUU1dVuD3s0h5DCozKtRuFxYWI#_7 http://www.w3.org/ns/prov#value High-level, tissue-specific expression of the beta-globin genes requires the presence of an upstream locus control region (LCR). The overall enhancer activity of the beta-globin complex LCR (beta-LCR) is dependent on the integrity of the tandem NF-E2 sites of HS-2. The NF-E2 protein which binds these sites is a heterodimeric basic leucine zipper protein composed of a tissue-specific subunit, p45 NF-E2, and a smaller subunit, p18 NF-E2, that is widely expressed. .... Reduced levels of both alpha- and beta-globin were associated with the lower levels of NF-E2 activity in this cell line. Globin expression was fully restored upon the introduction of a tethered p45-p18 heterodimer. .... From these results, we conclude that NF-E2 is specifically required for high level goblin gene expression in MEL cells. http://www.tkuhn.ch/bel2nanopub/RAjfSP_1GoUC4kmGsYZuUU1dVuD3s0h5DCozKtRuFxYWI#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/7623856 http://www.tkuhn.ch/bel2nanopub/RAjfSP_1GoUC4kmGsYZuUU1dVuD3s0h5DCozKtRuFxYWI#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAjfSP_1GoUC4kmGsYZuUU1dVuD3s0h5DCozKtRuFxYWI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/7623856 http://www.tkuhn.ch/bel2nanopub/RAjfSP_1GoUC4kmGsYZuUU1dVuD3s0h5DCozKtRuFxYWI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAjfSP_1GoUC4kmGsYZuUU1dVuD3s0h5DCozKtRuFxYWI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAjfSP_1GoUC4kmGsYZuUU1dVuD3s0h5DCozKtRuFxYWI#_7 http://www.tkuhn.ch/bel2nanopub/RAjfSP_1GoUC4kmGsYZuUU1dVuD3s0h5DCozKtRuFxYWI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAjfSP_1GoUC4kmGsYZuUU1dVuD3s0h5DCozKtRuFxYWI http://purl.org/dc/terms/created 2014-07-03T14:33:45.788+02:00 http://www.tkuhn.ch/bel2nanopub/RAjfSP_1GoUC4kmGsYZuUU1dVuD3s0h5DCozKtRuFxYWI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAjfSP_1GoUC4kmGsYZuUU1dVuD3s0h5DCozKtRuFxYWI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234