@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP326817.RAjde7Aw5V7WhCFDTQhcsaBrli3AVGUXc0aCBMn2jHde8> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP326817.RAjde7Aw5V7WhCFDTQhcsaBrli3AVGUXc0aCBMn2jHde8130_head {
  this: np:hasAssertion dgn-np:NP326817.RAjde7Aw5V7WhCFDTQhcsaBrli3AVGUXc0aCBMn2jHde8130_assertion;
    np:hasProvenance dgn-np:NP326817.RAjde7Aw5V7WhCFDTQhcsaBrli3AVGUXc0aCBMn2jHde8130_provenance;
    np:hasPublicationInfo dgn-np:NP326817.RAjde7Aw5V7WhCFDTQhcsaBrli3AVGUXc0aCBMn2jHde8130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP326817.RAjde7Aw5V7WhCFDTQhcsaBrli3AVGUXc0aCBMn2jHde8130_assertion a np:Assertion .
  
  dgn-np:NP326817.RAjde7Aw5V7WhCFDTQhcsaBrli3AVGUXc0aCBMn2jHde8130_provenance a np:Provenance .
  
  dgn-np:NP326817.RAjde7Aw5V7WhCFDTQhcsaBrli3AVGUXc0aCBMn2jHde8130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP326817.RAjde7Aw5V7WhCFDTQhcsaBrli3AVGUXc0aCBMn2jHde8130_assertion {
  miriam-gene:8548 a ncit:C16612 .
  
  lld:C0023473 a ncit:C7057 .
  
  dgn-gda:DGN2f5463f348c3d952bbd543c8e087fc95 sio:SIO_000628 miriam-gene:8548, lld:C0023473;
    a sio:SIO_001121 .
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dgn-np:NP326817.RAjde7Aw5V7WhCFDTQhcsaBrli3AVGUXc0aCBMn2jHde8130_provenance {
  dgn-np:NP326817.RAjde7Aw5V7WhCFDTQhcsaBrli3AVGUXc0aCBMn2jHde8130_assertion dcterms:description
      "[By making use of receptor-Ck positive lymphocytes (from normal human subjects) as well as receptor-Ck negative lymphocytes (from untreated chronic myeloid leukemic (CML) patients) as cellular models, we were able to show that receptor-Ck-dependent signalling is involved in the regulation of genes coding for Bcl-2 and cyclin D. Further, experiments directed to resolve the mechanism by which this receptor regulates these genes revealed that receptor-Ck, upon activation by cholesterol, initiates the cleavage of a 125 kDa cytoplasmic protein leading to the generation of a 47 kDa factor having specific affinity for genomic sterol regulatory element (SRE)/SRE-like sequence present in the promoter region of genes coding for Bcl-2 and cyclin D. Based upon these observations, we propose that the inability of leukemic cells to express receptor-Ck is responsible for the deregulated over-expression of genes coding for Bcl-2 and cyclin D and this phenomenon may be of importance in understanding leukemic haematopoiesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:9680093;
    prov:wasDerivedFrom dgn-void:befree-20140225;
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  dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP326817.RAjde7Aw5V7WhCFDTQhcsaBrli3AVGUXc0aCBMn2jHde8130_publicationInfo {
  this: dcterms:created "2014-10-02T12:35:11+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v2.1.0.0" .
  
  dgn-void:disgenetrdf pav:version "v2.1.0" .
}